Talking about marijuana can be complicated. More and more states are legalizing it for adults for both medical and recreational use—but the research is mixed when it comes to the medical benefits vs. the risks. What we do know are some of the effects it has on your brain and body when you use it, and that’s key knowledge for making informed decisions.
How marijuana makes people feel varies—a lot
“When marijuana is smoked, tetrahydrocannabinol, or THC (the main active ingredient), and other chemicals quickly reach their target receptors in the brain, and the user experiences the effects almost immediately,” says Dr. Ruben Baler, neuroscientist and marijuana researcher at the National Institute on Drug Abuse, Washington DC. “Some of these include a sense of euphoria and relaxation, but pleasant experiences are by no means universal. Some users experience anxiety, fear, or panic.”
Recent research shows that young people in both high school and college think of marijuana as lower risk than students in the past did, which may have to do with increasing legalization.
“In terms of legalization, yes, there are chemicals in marijuana that have the potential to benefit patients with specific conditions—but legalized recreational use has given people the wrong perception that the drug is completely safe. More research is needed to pinpoint long-term effects, but what we do know is that THC can directly affect the way in which the brain processes information.”
—Dr. Ruben Baler, neuroscientist and researcher at the National Institute on Drug Abuse, Washington DC
Keep in mind that, like with alcohol, a person still must be age 21 or older to use marijuana in states that have legalized recreational use.
To cut the confusion, we collected the evidence. Here’s how the human body reacts to marijuana, both in the short term and over time.
Marijuana immediately triggers a boost of dopamine (a neurotransmitter that affects your brain’s pleasure center), which leads to those famous warm and fuzzy feelings (the “high”). But one 2016 study suggests that this may not be the case for everyone. The study—published in Molecular Psychiatry—found that heavy marijuana users (those who used at least twice per day, five days a week or more) had lower dopamine releases over time, which is associated with not only decreased happiness but also worsened memory and a struggle with performing tasks that require attention.
Overall, there isn’t enough evidence to make claims about the long-term effects of marijuana on the brain. However, a 2014 study in the Journal of Neuroscience found significant brain differences (in size and shape of areas associated with decision making) in the MRI results of 18- to 25-year-olds who smoked marijuana at least once a week (compared to people with little or no prior experience with marijuana).
THC decreases blood pressure, causing capillaries and blood vessels to dilate. Besides the telltale red eyes (caused by increased blood flow) and the dryness that usually accompanies it, there’s some evidence to show that marijuana could actually damage your vision in the long run. According to a 2017 study in JAMA Ophthalmology, regular use has been shown to hinder how your retina cells processes visual information, which the researchers suggested could potentially alter vision.
Unlike smoking tobacco cigarettes, researchers have not found a clear link between lung cancer and smoking marijuana. However, a 2008 study in Chemical Research in Toxicology found that marijuana smoke contains similar toxic chemicals to those found in tobacco cigarette smoke, such as ammonia (commonly found in pesticides) and hydrogen cyanide (a poisonous chemical compound). The main takeaway: We still don’t know exactly what’s going on with marijuana’s effect on the lungs, but research shows that regular marijuana smokers are more likely to experience wheezing, excess phlegm production, and a stubborn cough.
There’s lots of disagreement when it comes to marijuana and its effects on your heart. While one recent study that analyzed 20 million health records found a 10 percent increased risk of heart failure and a 26 percent increased risk of stroke among users, other long-term studies haven’t found a strong-enough correlation between marijuana use (with no tobacco) and any increased risk. One thing experts all agree on: More research is needed.
One of marijuana’s most notorious side effects is also its most mysterious. Even some of the world’s top researchers can’t pinpoint exactly why marijuana often sparks a ravenous hunger (also known as the “munchies”) that leads people to raid the fridge or the nearest convenience store. So far, it’s believed that the key lies in the CB1 receptors within our brain, which trigger feelings of being full or hungry. THC seems to activate a hunger-promoting hormone that tells us we’re hungry, even if we aren’t.
Edible marijuana products (such as baked goods, candies, and beverages) are popular in states that have legalized recreational and medicinal use (Methods Report, 2016). Edibles don’t carry the same risks associated with smoking (though such little research has been conducted on them, we really don’t know what effect they could have on our health). What we do know is that there are some stark differences in how THC affects the body when it’s consumed vs. when it’s smoked.
For example, when a person smokes marijuana, they usually start feeling the effects within 10 minutes, and the high lasts for about 4 hours. When a person consumes edibles, it takes at least 30 minutes to start feeling the effects; it peaks about 3 hours in and lasts for about 12 hours (JAMA, 2015). This delay in onset and the much longer duration can make it difficult for people to figure out how much THC they’ve consumed or gauge how it will make them feel, which could be leading people to inadvertently consume too much. A 2015 study in JAMA found that most people going to the hospital in Colorado for marijuana intoxication (with symptoms like anxiety, panic attacks, and vomiting) had ingested edible THC products.
Studies show THC majorly affects your reaction time and motor coordination, and it’s correlated with impaired driving. The number of car accident-related insurance claims in Colorado, Washington, and Oregon increased by about 3 percent since the three states legalized marijuana for recreational use, according to a report by the Insurance Institute for Highway Safety. In fact, aside from alcohol, it’s the drug most commonly detected in the blood of drivers who’ve been in a car crash, according to the National Institute on Drug Abuse (NIDA). Whether or not you choose to use marijuana, never get behind the wheel while you’re impaired (or get in the car with a driver who is). Not only could you be pulled over and charged for driving under the influence (which usually comes with a massive fine and license suspension), but also you could also cause a fatal accident.
OK, so even if you’re not trying to start a family anytime soon, keep in mind that a common cause of infertility is oddly shaped, confused, or “lazy” sperm. A 2014 study showed young men who smoked marijuana had higher levels of these wonky sperm and had fewer of the strong swimmers required to fertilize an egg and make a baby (this doesn’t mean marijuana works as a contraceptive, though—it’s definitely still possible to get someone pregnant while high). This study pinpointed three months as the maximum affected period, and the long-term effects aren’t clear. The research on how marijuana use may affect women’s fertility is limited and still unclear. However, pregnant women who use marijuana may have twice as high a risk of having a stillborn baby compared to non-users, and there may be other detrimental effects on the developing fetus, according to NIDA.
Ruben Baler, PhD, neuroscientist and researcher at the National Institute on Drug Abuse, Washington DC.
American College of Cardiology. (2017, March 9). Marijuana use associated with increased risk of stroke, heart failure. Retrieved from https://www.acc.org/about-acc/press-releases/2017/03/09/14/05/marijuana-use-associated-with-increased-risk-of-stroke-heart-failure
Brady, J. E., & Li, G. (2014). Trends in alcohol and other drugs detected in fatally injured drivers in the United States, 1999–2010. American Journal of Epidemiology, 179(6), 692–699. doi:10.1093/aje/kwt327
Crean, R. D., Crane, N. A., & Mason, B. J. (2011). An evidence-based review of acute and long-term effects of cannabis use on executive cognitive functions. Journal of Addiction Medicine, 5(1), 1. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037578/
DeNoon, D. J. (2003). Smoking marijuana lowers fertility. WebMD. Retrieved from https://www.webmd.com/men/news/20031013/smoking-marijuana-lowers-fertility#1
Giessen, E. V., Weinstein, J. J., Cassidy, C. M., Haney, M., et al. (2016). Deficits in striatal dopamine release in cannabis dependence. Molecular Psychiatry, 22(1), 68–75. doi:10.1038/mp.2016.21
Gilman, J. M., Kuster, J. K., Lee, S., Lee, M., et al. (2014). Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. Journal of Neuroscience, 34(16), 5529–5538. doi:10.1523/jneurosci.4745-13.2014
Johnston, L. D., O’Malley, P. M., Bachman, J. G., & Schulenberg, J. E. (2017). Monitoring the future: National results on adolescent drug use: Overview of key findings, 2008. Institute for Social Research. Retrieved from: https://www.monitoringthefuture.org//pubs/monographs/mtf-vol2_2016.pdf
Joshi, M., Joshi, A., & Bartter, T. (2014). Marijuana and lung diseases. Current Opinion in Pulmonary Medicine, 20(2), 173–179. doi:10.1097/mcp.0000000000000026
Jouanjus, E., Lapeyre-Mestre, M., & Micallef, J. (2014). Cannabis use: Signal of increasing risk of serious cardiovascular disorders. Journal of the American Heart Association, 3(2). doi:10.1161/jaha.113.000638
Koch, M., Varela, L., Kim, J. G., Kim, J. D., et al. (2015). Hypothalamic POMC neurons promote cannabinoid-induced feeding. PubMed.gov. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25707796
Lenné, M. G., Dietze, P. M., Triggs, T. J., Walmsley, S., et al. (2010). The effects of cannabis and alcohol on simulated arterial driving: Influences of driving experience and task demand. Accident Analysis & Prevention, 42(3), 859–866. doi:10.1016/j.aap.2009.04.021
Mayo Clinic. (2013). Marijuana (Cannabis sativa) safety. Retrieved from https://www.mayoclinic.org/drugs-supplements/marijuana/safety/hrb-20059701
Moir, D., Rickert, W. S., Levasseur, G., Larose, Y., et al. (2008). A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke produced under two machine smoking conditions. Chemical Research in Toxicology, 21(2), 494–502. doi:10.1021/tx700275p
National Institute on Drug Abuse. (June 2016). Drugged driving. Retrieved from https://www.drugabuse.gov/publications/drugfacts/drugged-driving
NIDA. (2016). Monitoring the future survey: High school and youth trends. Retrieved from https://www.drugabuse.gov/publications/drugfacts/monitoring-future-survey-high-school-youth-trends
Pacey, A. A., Povey, A. C., Clyma, J. A., McNamee, R., et al. (2014). Modifiable and non-modifiable risk factors for poor sperm morphology. Human Reproduction, 29(8), 1629–1636. doi:10.1093/humrep/deu116
Pietrangelo, A., & Cherney, K. (2017, July 21). The effects of marijuana on your body. Healthline. Retrieved from https://www.healthline.com/health/addiction/marijuana/effects-on-body
Pletcher, M. J., Vittinghoff, E., Kalhan, R., Richman, J., et al. (2012). Association between marijuana exposure and pulmonary function over 20 years. JAMA, 307(2), 173–181.
Ribeiro, L. I., & Ind, P. W. (2016). Effect of cannabis smoking on lung function and respiratory symptoms: A structured literature review. Npj Primary Care Respiratory Medicine, 26(1). doi:10.1038/npjpcrm.2016.71
Sansone, R. A., & Sansone, L. A. (2014, July). Marijuana and body weight. Innovations in Clinical Neuroscience, 11(7–8), 50–54. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204468/
Schwitzer, T., Schwan, R., Albuisson, E., Giersch, A., et al. (2017). Association between regular cannabis use and ganglion cell dysfunction. JAMA Ophthalmology, 135(1), 54. doi:10.1001/jamaophthalmol.2016.4761
Vimont, C., & Maturi, R. K. (2017, February 28). Studies look at effects of marijuana on vision. American Academy of Ophthalmology. Retrieved from https://www.aao.org/eye-health/news/studies-look-at-effects-of-marijuana-on-vision